سال انتشار: ۱۳۹۰
محل انتشار: اولین همایش ملی نانومواد و نانو تکنولوژی
تعداد صفحات: ۱۴
Kourosh Motevalli – applied chemistry department,technical & engineering faculty,Islamic azad university,south Tehran branch,Tehran,iran
Zahra Yaghoubi – address:industrial faculty,Islamic azad university,south Tehran branch,Tehran,iran
An efficient and environmentally friendly sample preparation method based on the application of hydrophobic 1-Hexylpyridinium hexafluorophosphate [Hpy][PF6] ionic liquid (IL) as a microextractionsolvent was proposed to preconcentrate amphetamine . In these work nanoparticles of copper was applied to increase the extraction efficiency.[Hpy][PF6] was employed as the microextraction solvent due to some physicochemical properties like high hydrophobicity, water immiscibility and quite viscosity. The performance of the microextraction method was improved by introducing a common ion of pyridinium IL into the sample solution. Due to the presence of the common ion, the solubility of IL significantly decreased. As a result, the phase separation successfullyoccurred even at high ionic strength, and the volume of the settled IL-phase was not influenced by variations in the ionic strength (up to 30% w/v). After preconcentration step, the enriched phase was introduced to the spectrofluorimeter for the determination of Amphetamine. The obtained results revealed that this system did not suffer from the limitations of that in conventional ionic-liquid microextraction. Under optimum experimentalconditions, the proposed method provided a limit of detection (LOD) of0.027 μg L-1 and a relative standard deviation (R.S.D.) of 2.4%. The present method was successfully applied to Amphetamine determination in actual pharmaceutical formulations and biological samples. Considering the large variety of ionic liquids, the proposed microextraction method earns manymerits, and will present a wide application in the future.