سال انتشار: ۱۳۹۰
محل انتشار: کنفرانس بین المللی فرآورش پلیمرها
تعداد صفحات: ۵
Solmaz Eskandarion – Dental Materials Department, Faculty of Dentistry, Research Centre of Science and technology in Medicine, Tehran University of Medical sciences, Tehran, Iran
Mehdi Esfandyari-Manesh – Nanotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Rassoul Dinarvand – Nanotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Tahere Jafarzadeh Kashi –
Biodegradable in-situ gels are useful prospects for the delivery of drugs into periodontal pockets. The nanoparticle system provides several advantages as compared with emulsion-based delivery systems and microparticles, including high dispersibility in an aqueous medium, controlled drug release, and increased stability. Nanoparticles penetrate regions that may be inaccessible to other systems, such as the periodontal pocket below the gum line. The objective of this study was to prepare a novel thermal gelation biodegradable polymer containing antibiotic-PLGA nanoparticles that gels at body temperature for local releasing of antibiotics and decreasing the systematic antibiotic dosage for patients. PLGA-PEG-PLGA tri-block copolymers were synthesized by ring-opening method. PLGA nanoparticles (376 nm of size, 2.62% of drug loading) incorporating ciprofloxacin was prepared by Water/Oil/Water emulsification solvent evaporation method. The molecular weight of resulting tri-block copolymers determined by gel permeation chromatography (GPC) was approximately 4350. H-NMR spectrum was used for structure analysis (22.03% glycolide content). The tri-block copolymers were soluble in water, forming a free-flowing solution that spontaneously gels at body temperature to create a water-insoluble gel. Interconversion between the sol and gel state has been repeated through numerous cycles without evidence of change. The in-situ gels containing drug-nanoparticles provided the excellent local delivery of antibiotics, comparing with drug released from nanoparticles, that is simple to process and administer. Nanoencapsulation of drug was shown that ciprofloxacin nanoparticles could considerably improve the ciprofloxacin antibacterial efficacy.