سال انتشار: ۱۳۸۸

محل انتشار: همایش ملی کاربرد نانوتکنولوژی در علوم محض و کاربردی

تعداد صفحات: ۷

نویسنده(ها):

Keivan Ghodrati – Chemistry Department, Faculty of BasicScience, Islamic Azad University, Kermanshah, Iran
Azita Farokhi –
Changiz Karami –
Maryam Goodarzi –

چکیده:

An efficient synthesis of 3,4 3,4-dihydropyrimidinones or thiones (DHPMs) is described, using nano silica SiO2 for the first time as the catalyst from an aldehyde β-keto ester and urea or thiourea in acetonitrile. Compared to the classical Biginelli reaction conditions, this method consistently has the advantage of excellent yields, mild reaction conditions, ease of workup, survival of different functional groups, and short reaction times.