سال انتشار: ۱۳۸۷

محل انتشار: دومین کنگره بین المللی علوم و فناوری نانو

تعداد صفحات: ۲

نویسنده(ها):

S Alipour – Textile Department, Guilan University,P.O. Box 41635-3756, Rasht,IRAN
M Nouri –
S.H Bahrami – Textile Department, Amirkabir University of Technilogy
B Noroozi –

چکیده:

Chitosan, the deacetylated derivative of chitin, is the second most abundant polysaccharide found on earth next to cellulose. As a natural renewable resource, Chitosan has a number of unique properties such as antimicrobial activity, nontoxicity, and biodegradability, which attract scientific and industrial interest in such fields as biotechnology, pharmaceutics, wastewater treatment, cosmetics, agriculture, food science, and textiles. However, this activity is limited to acidic conditions due to its poor solubility above pH~6.5, where Chitosan start to lose its cationic nature [1]. Water solubility is important in applications of Chitosan as an antimicrobial agent. Quaternised Chitosan (HTCC) derivatives have shown higher activity against bacteria, broader spectrum of activity and higher killing rate as compared to those of Chitosan. Various water soluble Chitosan derivatives with enhanced antimicrobial property were reviewed in recent papers. The reported quaternary ammonium salts from the reaction of Chitosan Schiff base with methyl iodide have strong antibacterial activity, but the cost is very high by using expensive reagents such as NaBH4 and CH3I[2]. The other kind of quaternized Chitosan, which is simply synthesized by the reaction of chitosan with glycidyl trimethyl ammonium chloride, has been reported. The antimicrobial activity of HTCC was much higher than that of Chitosan because of the synergisticeffect of the secondary amino groups and the quarternary ammonium groups of HTCC compared with the low effectiveness of primary amino groups in Chitosan under neutral conditions [3]. Electrospinning is an attractive approach to the fabrication of nano-fibrous materials for variety Polymers. Nanofibers having intrinsic bacteriostatic and/or bactericidal activity are of interest as wound-dressing materials, vascular grafts, drugdelivery, sensors and filter. Electrospun mats from ultrafine polymer fibres are drawing a great attention because of their unique properties such as high surface-to-volume ratio, high porosity and diameters in the nano-scale