سال انتشار: ۱۳۹۳

محل انتشار: پنجمین کنگره بین المللی نانو و فناوری نانو (ICNN2014)

تعداد صفحات: ۵

نویسنده(ها):

B Ghaemi – Department of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, Iran
A Amani – Department of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, Iran
Sh Kharrazi – Department of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, Iran
A.R Shahverdi – Department of Pharmaceutical biotechnology and Biotechnology Research Center, School of pharmacy, TehranUniversity of Medical Sciences, Tehran, Iran

چکیده:

significant cell death using novel X-Ray sensitive Gd and Eu doped ZnO Nanoparticles (NPs) has beenreported in this paper.Preferential integration of these materials into deep-solid tumors can augment efficiency ofradiotherapy. Herein, doping of Gd and Eu into the ZnO NPs is designed to optimize restricted energy absorption froma conventional radiotherapy. Upon irradiation, energy is transferred to the Zinc Oxide crystal structure, resulting in thegeneration of reactive oxygen species (ROS). In this experiment, Gd and Eu doped and undoped ZnO NPs weresynthesized and optimized at size of 3nm. Cytotoxic effect of ZnO NPs was investigated in prostate cancer and normalfibroblast cells. Radiation enhancement by doped NPs was occurred at 20 micro.g/ml under 1.5 Gy X-Ray, which isequal with cell death of untreated cells under 6 Gy X-ray. It is worth noting that, these doped NPs can be used as aphoto inducer to increase the dose of X-rays and caused a reduction of received dose to the normal cells.