سال انتشار: ۱۳۹۳

محل انتشار: پنجمین کنگره بین المللی نانو و فناوری نانو (ICNN2014)

تعداد صفحات: ۴

نویسنده(ها):

M Khorramian – Department of Chemical Engineering, Guilan University, Rasht, Iran
S Ashraf Talesh – Department of Chemical Engineering, Guilan University, Rasht, Iran

چکیده:

In this study production of the nanoparticles of Indomethacin as a poorly water-soluble drug based on liquidantisolvent precipitation process was investigated. In this way the Continuous antisolvent production of drugnanoparticles was carried out with a confined liquid impinging jets. The SEM photomicrographs shown that theIndimethacin nanoparticles exhibited needle-like morphology and uniform PSD when compared to irregular shapecommercial Indomethacin. The result also indicated that the nanoparticles of Indomethacin can be prepared under theincreasing the drug concentration from 10mg/ml to 30mg/ml.