سال انتشار: ۱۳۸۹

محل انتشار: همایش منطقه ای یافته های نوین شیمی و مهندسی شیمی

تعداد صفحات: ۷

نویسنده(ها):

a rineh – antibiotic sazi iran co ASICO, khazarabad road sari iran
b pourrostam – antibiotic sazi iran co ASICO, khazarabad road sari iran
m sadatshahabi – antibiotic sazi iran co ASICO, khazarabad road sari iran
n eslami – antibiotic sazi iran co ASICO, khazarabad road sari iran

چکیده:

Preparation of 7-AVCA (I) includes 8 steps and 3intermediates which namely penicillin G sulphoxide ester C , GCLE F and GVNE G , respectively , in synthesis of 7-ADCA N , penicillin G (A)reacted with peracetic acid to give penicillin G sulphoxide Jyield: 90% , purity : 98%. in second step penicillin G sulphoxide was treated with bis trimethyl silyl urea BSU , acetyl bromide and pyridine which produce cephalosporin G(M)yield: 78% ,purity: 98% finally in third step using wet penicillin G amidase , cephalosporin G converted to 7- ADCA(N) (yield: 58% , purity 99% .